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Medicinal Chemistry-I PV (PeeVee) B.Pharm 4th sem Free PDF Download Ebook

 

 Medicinal Chemistry-I, B.Pharmacy 4th semester, PV (PeeVee) Free PDF Download Ebook

    PV Publication Medicinal Chemistry-I for B.pharmacy 4th semester ebook is one the most useful for B.Pharmacy students. Medicinal Chemistry-I subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs. The subject emphasizes on structure activity relationships of drugs, importance of physicochemical properties and metabolism of drugs. The syllabus also emphasizes on chemical synthesis of important drugs under each class.

Medicinal Chemistry ebook 4th Semester Free Download

Nirali Publication Medicinal Chemistry PDF 4th Semester

Medicinal Chemistry PV free pdf download

PV Medicinal Chemistry free ebook download

Medicinal Chemistry by Nirali free ebook download


Specs of PV Medicinal Chemistry ebook:

This ebook comprises of following features:
  • UNIT-I 
    • Introduction to Medicinal Chemistry
    • History and development of medicinal chemistry 
    • Physicochemical properties in relation to biological action 
      • Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism. 
    • Drug metabolism 
      • Drug metabolism principles- Phase I and Phase II. 
      • Factors affecting drug metabolism including stereo chemical aspects.
  • UNIT-II 
    • Drugs acting on Autonomic Nervous System 
    • Adrenergic Neurotransmitters: 
      • Biosynthesis and catabolism of catecholamine.
      • Adrenergic receptors (Alpha & Beta) and their distribution.
    • Sympathomimetic agents: SAR of Sympathomimetic agents
      • Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine, 90 Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.
      • Indirect acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine.
      • Agents with mixed mechanism: Ephedrine, Metaraminol. 
    • Adrenergic Antagonists: 
      • Alpha adrenergic blockers: Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide. 
      • Beta adrenergic blockers: SAR of beta blockers, Propranolol*, Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol, Metoprolol, Labetolol, Carvedilol. 
  • UNIT-III
    • Cholinergic neurotransmitters:
    • Biosynthesis and catabolism of acetylcholine.
    • Cholinergic receptors (Muscarinic & Nicotinic) and their distribution. D. Parasympathomimetic agents: SAR of Parasympathomimetic agents
    • Direct acting agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.
    • Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.
    • Cholinesterase reactivator: Pralidoxime chloride. 
    • E. Cholinergic Blocking agents: SAR of cholinolytic agents 
    • Solanaceous alkaloids and analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.
    • Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.
  • UNIT-IV
    • Drugs acting on Central Nervous System 
    • A. Sedatives and Hypnotics: 
    • Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem 
    • Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital 
    • Miscelleneous: 
    • Amides & imides: Glutethmide. 
    • Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol. 
    • Aldehyde & their derivatives: Triclofos sodium, Paraldehyde. 
    • B. Antipsychotics 
    • Phenothiazeines: SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride. 
    • Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine. 
    • Fluro buterophenones: Haloperidol, Droperidol, Risperidone. 
    • Beta amino ketones: Molindone hydrochloride. 
    • Benzamides: Sulpieride. 
    • C. Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant action 
    • Barbiturates: Phenobarbitone, Methabarbital. 
    • Hydantoins: Phenytoin*, Mephenytoin, Ethotoin 
    • Oxazolidine diones: Trimethadione, Paramethadione 
    • Succinimides: Phensuximide, Methsuximide, Ethosuximide* 
    • Urea and monoacylureas: Phenacemide, Carbamazepine* 
    • Benzodiazepines: Clonazepam 
    • Miscellaneous: Primidone, Valproic acid , Gabapentin, Felbamate 
  • UNIT-V
    • Drugs acting on Central Nervous System 
    • General anesthetics: 
    • Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane. 
    • Ultra short acting barbitutrates: Methohexital sodium*, Thiamylal sodium, Thiopental sodium. 
    • Dissociative anesthetics: Ketamine hydrochloride.* Narcotic and non-narcotic analgesics 
    • Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide hydrochloride, Fentanyl citrate*, Methadone hydrochloride*, Propoxyphene hydrochloride, Pentazocine, Levorphanol tartarate. 
    • Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride. 
    • Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone

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